منابع مشابه
Phosphodiesterase type 5 inhibitors: Irrational use in Saudi Arabia
OBJECTIVE To identify the criteria of phosphodiesterase type 5 inhibitor (PDE5i) users and to analyse the knowledge, attitude, and practices of PDE5i use amongst Saudi men. SUBJECTS AND METHODS A web-based, cross-sectional survey was conducted in Saudi Arabia between January and April 2015. Sexually active adult men were interviewed using a website questionnaire designed by the authors. Descr...
متن کاملAB030. Evolution of phosphodiesterase type 5 inhibitors
After launching of sildenafil citrate, the last invention of 20 century, in 1998, oral phosphodiesterase type 5 (PDE5) inhibitor has been established as first line treatment of erectile dysfunction and shift new paradigm of diagnosis and treatment of erectile dysfunction. The big success of sildenafil in pharmaceutical R&D induced the consecutive development of the so-called ‘The second Viagra’...
متن کاملPhosphodiesterase type 5 inhibitors for erectile dysfunction.
The cyclic nucleotide signalling pathway mediates the smooth-muscle relaxing effects of nitric oxide necessary for normal erectile function. Down-regulation of this pathway is central to the pathophysiology of many forms of erectile dysfunction (ED), which is often associated with other chronic diseases (e.g. hypertension, type 2 diabetes mellitus) and treatments (e.g. certain drugs, radical pr...
متن کاملInfluence on Saudi Arabia
"Broadcast" theory is one of the common theories explaining how phenomena and ideas spread. It is used by researchers in different fields of study. Having studied broadcast theory and its different components, this article tries to represent whether Islamic revolution of Iran has exerted influence on Saudi Arabia. And if positive, how it has influenced and how much it has been. The results sug...
متن کاملClinical use of phosphodiesterase-5 inhibitors in chronic heart failure.
Nowadays, the inhibitors of the phosphodiesterase enzyme type 5 (PDE5), thanks to a sustained relaxant activity on smooth muscles of the corpus cavernosum, are a widely used remedy for erectile dysfunction in man. This class of compounds was originally developed for the treatment of angina pectoris, based on the ability of oversignaling the pathway originated from nitric oxide (NO) and pursued ...
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ژورنال
عنوان ژورنال: Arab Journal of Urology
سال: 2016
ISSN: 2090-598X
DOI: 10.1016/j.aju.2016.03.003